9,12,13 For example, role of RBTN-2 as a proto-oncogene. 2,3 Recent transgenic studies have confirmed the a variety of protein-protein interactions. LIM domains have been shown to facilitate expressed. ![]() 1,2 and to some degree the length of the LIM domain loop porThese translocations almost invariably result in the high tions are variable, and thus confer each LIM domain its own expression of RBTN-2 in T cells where RBTN-2 is not normally specific function. The other amino acid residues, 2 locus (at 11p13) in childhood T cell acute leukemia. The implicated in T cell leukemogenesis by the high frequency of residues required for zinc cation-coordination and structural non-random chromosomal translocations involving the RBTNintegrity are highly conserved. Each LIM domain coordinates two zinc cations, which presumably hold the intervening residues in The proto-oncogene rhombotin-2 (RBTN-2) was initially loop-like structures reminiscent of zinc finger domains. For example, RBTN-2 likely regulates the expression of RBTN-2 binds other proteins via its two tandem LIM domains, which make up approximately two-thirds of its mass Introduction (reviewed in Ref. RBTN-2 may also regulate other Northern analyses showed similar levels of two elf-2 transcripts genes. This protein was named elf-2 because its DNA-binding domain is virtually identical to that of ets family member elf-1. By screening a T cell cDNA library, location of RBTN-2 in hematopoietic cells, 7 suggest that we identified a novel ets transcription factor that binds RBTN-RBTN-2 has a direct role in transcriptional regulation of 2. 9 These data, considered in light of the nuclear T cell-specific expression. RBTN-2 in T cells is likely mediated by binding protein(s) withand GATA-2. We postulated that the oncogenic effect of shown to bind erythroid transcription factors tal-1, GATA-1, For example, RBTN-2 has recently been of T lymphocytes. Rhombotin-2 (RBTN-2) is a proto-oncogene only in the context transcription factors. Blanco: contribución en el diseño del estudio, participación en la fase de campo y revisión crítica del manuscrito Results: We found a 10% seroprevalence (8/80) and the viral genome was detected in 16 brain samples the alignment (BLAST) and the phylogenetic analysis (MrBayes, version 3.2.2) confirmed the presence of the lymphocytic choriomeningitis virus.Ĭonclusion:The results indicated that human infection with the lymphocytic choriomeningitis virus in humans could occur in the urban area of Sincelejo, although no cases have been reported so far. ![]() Silvana Levis: donación de reactivos no comerciales y asesoría en los ensayos, revisión crítica y aportes a la discusión Pedro J. Díaz: revisión crítica y asesoría del contenido, aportes a la discusión y análisis filogenéticos. Rodas y Andrés Londoño: trabajo de laboratorio, asesoría en la revisión y aportes a la discusión Francisco J. Contribución de los autores:Anaís Castellar: revisión de la literatura científica, recolección y análisis de datos y redacción del manuscrito Marco Guevara y Esteban Arroyave: trabajo de campo y organización de los datos Juan D.
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