![]() ![]() ![]() Early diagnosis and timely and appropriate clinical management of sepsis, such as optimal antimicrobial use and fluid resuscitation, are crucial to increase the Implementing preventive measures against infections, such as good hygiene practices, ensuring access to vaccination programmes, improved sanitation and water quality and availability, and other infection prevention and control best practices both in theĬommunity and health care settings, are key steps in reducing the occurrence of sepsis. Sepsis patients with resistant pathogens have been found to have a higher risk of hospital mortality. Antimicrobial resistance is a major factor determining clinical unresponsiveness to treatment and rapid evolution to sepsisĪnd septic shock. Healthcare-associated infections are often resistant to antibiotics and can rapidly lead to deteriorating clinical conditions. Sepsis also frequently results from infections acquired in health care settings, which are one of the most frequent adverse events duringĬare delivery and affect hundreds of millions of patients worldwide every year (2). In the community setting, sepsis often presents as the clinical deterioration of common and preventable infections. Of infection, particularly in low- and middle-income countries where it represents a major cause of maternal and neonatal morbidity and mortality. It is most frequently a serious complication If not recognized early and managed promptly, it can lead to septic shock, multiple organ failure and death. Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection (3). Since these infections are often resistant to antibiotics, they can rapidly lead to deteriorating clinical conditions. Health care-associated infections are one of, if not the most frequent type of adverse event to occur during care delivery and affect hundreds of millions of patients worldwide every year (2). Sepsis can be the clinical manifestation of infections acquired both in the community setting or in health care facilities.Significant regional disparities in sepsis incidence and mortality exist approximately 85.0% of sepsis cases and sepsis-related deaths worldwide occurred in low- and middle-income countries (1).In 2017, almost half of all global sepsis cases occurred among children, with an estimated 20 million cases and 2.9 million global deaths in children under five years of age (1).The global burden of sepsis is difficult to ascertain, although a recent scientific publication estimated that in 2017 there were 48.9 million cases and 11 million sepsis-related deaths worldwide, which accounted for almost 20% of all global deaths (1).Sepsis is a syndromic response to infection and is frequently a final common pathway to death from many infectious diseases worldwide.
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